Design, Synthesis, Characterization, and Antimicrobial Screening of Novel Indazole Bearing Oxadiazole Derivatives

作者：Ghelani Satish M; Khunt Hasmukh R; Naliapara Yogesh T

来源：Journal of Heterocyclic Chemistry, 2017, 54(1): 65-70.

DOI：10.1002/jhet.2540

[GRAPHICS]
Ethyl 2-(2,6-dioxocyclohexyl)-2-oxoacetate was prepared by reacting cyclohexane-1,3-dione (1) and diethyl oxalate (2) with the help of sodium ethoxide in ethanol at 0-5 degrees C. Subsequent treatment of ethyl 2-(2,6-dioxocyclohexyl)-2-oxoacetate with hydrazine hydrate in ethanol resulted into ethyl 4-oxo4,5,6,7- tetrahydro-2H-indazole-3-carboxylate while without solvent in excess hydrazine hydrate on reflux resulted into 4-oxo-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide (3). The synthesis of novel indazole bearing oxadiazole derivatives (ODZ 01 to 16) has been achieved by the reaction of hydrazide of 2H-indazole (3) with acid (4a-p) in the presence of POCl3, and the antimicrobial activity of synthesized novel compounds has been studied.

• 出版日期2017-1