Development of Electrochemical Aptasensor for Label-Free Glioma Cell Detection

作者:Zhao, Xianjun; Fang, Rongjin; Zhang, Yunfeng*
来源:International Journal of Electrochemical Science, 2017, 12(10): 9301-9310.
DOI:10.20964/2017.10.06

摘要

This work explored the fabrication of a functionalized graphene-and-aptamer AS1411-based electrochemical sensor to achieve tag-free cancer cell determination. The proposed electrochemical aptasensor could distinguish between normal cells and glioma cells with a low detection limit due to the excellent binding affinity and specificity of AS1411 to the overexpressed nucleolin on the surface of the glioma cells.