A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of I-125-imaging agents

作者:Sloan Nikki L; Luthra Sajinder K; McRobbie Graeme; Pimlott Sally L; Sutherland Andrew*
来源:Chemical Communications, 2017, 53(80): 11008-11011.
DOI:10.1039/c7cc06211g

摘要

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing latestage, rapid access to a wide range of I-125-labelled aryl compounds and SPECT radiotracers.

  • 出版日期2017-10-14