Amyloid-beta Associated Volume Loss Occurs Only in the Presence of Phospho-Tau

作者：Desikan Rahul S; McEvoy Linda K; Thompson Wesley K; Holland Dominic; Roddey J Cooper; Blennow Kaj; Aisen Paul S; Brewer James B; Hyman Bradley T; Dale Anders M^*

来源：Annals of Neurology, 2011, 70(4): 657-661.

DOI：10.1002/ana.22509

The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-beta (A beta) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF A beta(1-42). We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF A beta(1-42) only with elevated CSF p-tau(181p). Our findings indicate that neurodegeneration-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia. ANN NEUROL 2011;70:657-661

• 出版日期2011-10