Aneugenic effect of ionizing radiation in mammalian and human somatic cells

作者：Vasilyev S A^*; Timoshevsky V A; Lebedev I N

来源：Russian Journal of Genetics, 2009, 45(12): 1403-1412.

DOI：10.1134/S1022795409120011

Aneuploidy is among the most serious impairments of hereditary material in somatic and germline cells of living organisms. Chromosome loss or the appearance of an extra homolog in the chromosome set can result in either cell death or the development of various neoplasms with high probability of malignancy. It was traditionally believed that ionizing radiation produces primarily a clastogenic effect. However, there is apparently an aneugenic component of radiation, with mechanism different from that of structural chromosome damage. The present review focuses on the evidence for the existence of the aneugenic effect of ionizing radiation in mammalian and human somatic cells.

• 出版日期2009-12
• 单位河北医科大学