摘要
SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. OBJECTIVE: To determine the association between household food insecurity and interferon-gamma (IFN-gamma) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-gamma release assay. Logistic regression was used to identify factors associated with food insecurity. RESULTS: Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-gamma concentration of 4.2 III/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-gamma concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR 1.6, 95%CI 2.9 to 0.27, P = 0.02) and the number of adults in the household (OR 0.08, 95%CI 0.16 to 0.01, P = 0.03). There was no association between food insecurity and IFN-gamma response to Mycobacterium tuberculosis antigen. CONCLUSION: Food insecurity in pregnancy is associated with low IFN-gamma levels. There was no association between food insecurity and IFN-gamma response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.
- 出版日期2017-7
- 单位西北大学