GSTT1 Null Genotype Contributes to Lung Cancer Risk in Asian Populations: A Meta-Analysis of 23 Studies

作者：Yang Xin; Qiu Man Tang; Hu Jing Wen; Wang Xiao xiao; Jiang Feng; Yin Rong^*; Xu Lin

来源：PLos One, 2013, 8(4): e62181.

DOI：10.1371/journal.pone.0062181

Background: Genetic variation in glutathione S-transferases (GSTs) may contribute to lung cancer risk. Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results.
Methodology/Principal Findings: We performed a meta-analysis of 23 studies including 4065 cases and 5390 controls. We assessed the strength of the association of GSTT1 with lung cancer risk and performed sub-group analyses by source of controls, smoking status, histological types, and sample size. A statistically significant correlation between GSTT1 null genotype and lung cancer in Asian population was observed (OR = 1.28, 95% CI = 1.10, 1.49; P-heterogeneity < 0.001 and I-2 = 62.0%). Sub-group analysis revealed there was a statistically increased lung cancer risk in ever-smokers who carried the GSTT1 null genotype (OR = 1.94, 95% CI = 1.27, 2.96; P heterogeneity = 0.02 and I-2 = 58.1%). It was also indicated that GSTT1 null genotype could increase lung cancer risk among population-based studies (OR = 1.25, 95% CI = 1.04, 1.50; P-heterogeneity = 0.003 and I-2 = 56.8%). The positive association was also found in studies of sample size (<= 500 participants) (OR = 1.34, 95% CI = 1.10, 1.62; P-heterogeneity < 0.001 and I-2 = 65.4%).
Conclusions: These meta-analysis results suggest that GSTT1 null genotype is associated with a significantly increased risk of lung cancer in Asian population.

• 出版日期2013-4-24
• 单位江苏省肿瘤防治研究所; 南京医科大学