A novel 8-hydroxyquinoline-pyrazole based highly sensitive and selective Al(III) sensor in a purely aqueous medium with intracellular application: experimental and computational studies

作者：Islam Abu Saleh Musha; Bhowmick Rahul; Mohammad Hasan; Katarkar Atul; Chaudhuri Keya; Ali Mahammad^*

来源：New Journal of Chemistry, 2016, 40(5): 4710-4719.

DOI：10.1039/c5nj03153b

A new 8-hydroxyquinoline-pyrazole based highly sensitive and selective Al3+ sensor, 8Q-NH-Pyz (H2L3), was found to exhibit a turn-on fluorescence enhancement (FE) as high as 157 fold with K-d = (1.76 +/- 0.06) x 10(-5) M. The 1:1 binding stoichiometry was revealed from the linear fit of (F-max - F-0)/(F - F-0) vs. 1/[Al3+] of the fluorescence titration data which was further substantiated by Job's method and HRMS studies. The LOD determined by 3 sigma methods was found to be 4.29 nM and quantum yields were determined to be 0.002 and 0.28 for the ligand and its Al3+ complex, respectively. The tentative coordination environment in the [Al(L-3)(H2O)](+) complex was delineated by DFT calculations. TDDFT calculations reveal spectral features comparable to the experimental ones. This constitutes the first report on the fluorescence sensing of Al3+ and hence F- in a purely aqueous medium.

• 出版日期2016