科研之友
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摘要
Despite significant improvements in diabetes mellitus therapy, increasing disease duration and diabetes-related complications such as microangiopathy and neuropathy remain a severe problem affecting quality of life, morbidity, and mortality in diabetes. Pathogenesis centres on chronic hyperglycaemia and denaturation of multiple functional proteins with HbA(1c) as the gold standard, and oxidative stress plays a key role in the degradation of endothelial layers in target organs. Excessive blood glucose excursions and dyslipidaemia with lipotoxicity interact with these pathogenic cascades in a vicious circle, requiring a holistic therapy approach.
- 出版日期2016-10
