Robot-assisted laparoscopic radical prostatectomy in men with human immunodeficiency virus

作者：Silberstein J L^*; Parsons J K; Palazzi Churas K; Downs T M; Sakamoto K; Derweesh I H; Woldrich J; Kane C J

来源：Prostate Cancer and Prostatic Diseases, 2010, 13(4): 328-332.

DOI：10.1038/pcan.2010.35

• HIV
• AIDS
• robot-assisted laparoscopic prostatectomy
• HAART
• radical prostatectomy

The aim of this study is to evaluate the outcomes of robot-assisted laparoscopic prostatectomy (RALP) in prostate cancer (PCa) patients with human immunodeficiency virus (HIV). This is a prospective cohort study of HIV patients undergoing RALP, comparing the demographics, tumor characteristics, complications, and short-term oncological outcomes of HIV-positive men to HIV-negative men using univariate (chi(2), Mann-Whitney test) and multivariable (logistic regression) analyses. From 2007 to 2010, 298 men underwent RALP, 8 of whom were known to be HIV positive. Preoperatively, all eight were taking highly active antiretroviral therapy (HAART) and had undetectable viral loads (<50); mean CD4 count was 634 cells per mm(3). HIV-positive men were younger (54 versus 62 years, P = 0.010) and less likely to be white (P = 0.007). There were no significant differences between groups with respect to clinical staging, pathological and oncological outcomes or most complication rates. However, the prevalence of perioperative transfusions (P = 0.031) and ileus (P = 0.021) were higher in HIV-positive patients. HIV remained significantly associated with risk of transfusion after adjustment for age, race, Gleason sum and clinical T stage (P = 0.002). After a median of 2.6 (range 0.03-19.2) months of follow-up, PSA remained undetectable in all eight HIV patients. These data suggest that RALP is safe for, and demonstrates short-term oncological efficacy in, HIV-positive patients with PCa. Prostate Cancer and Prostatic Diseases (2010) 13, 328-332; doi: 10.1038/pcan.2010.35; published online 28 September 2010

• 出版日期2010-12