An efficient microwave-assisted enzyme-catalyzed regioselective synthesis of long chain acylated derivatives of flavonoid glycosides

作者：Ziaullah; Rupasinghe H P Vasantha^*

来源：Tetrahedron Letters, 2013, 54(15): 1933-1937.

DOI：10.1016/j.tetlet.2013.01.103

• Isoquercitrin
• Phloridzin
• Acylation
• Microwave irradiation
• Candida antartica lipase B
• H-1 NMR
• C-13 NMR spectroscopy

This work describes a method of microwave-assisted regioselective enzymatic acylation, using Novozyme 435 (R), of quercetin-3-O-glucoside (isoquercitrin) and phloretin-2'-glucoside (phloridzin) with different long chain saturated, mono-, and poly-unsaturated fatty acids. The synthesized esters were analyzed by H-1 NMR, and C-13 NMR spectroscopy. In this investigation, microwave irradiation under solvent free condition has been found to be more efficient and economical than conventional conditions both, in terms of time and energy.

• 出版日期2013-4-10