Asymmetric synthesis of N-tosyl amino acids from N-sulfinyl alpha-amino-1,3-dithioketals

作者：Davis Franklin A^*; Ramachandar Tokala; Chai Jing; Qiu Hiu

来源：ARKIVOC, 2010, 17-26.

• Sulfinimine (N-sulfinyl imine)
• asymmetric synthesis
• N-tosyl alpha-amino acids
• N-sulfinyl alpha-amino-1,3-dithioketals

Hydrolysis of diastereomerically pure N-sulfinyl alpha-amino-1,3-dithianes with 1,3-dibromo-5,5-dimethylhydantoin gives N-tosyl alpha-amino aldehydes which when subjected to a Pinnick-type oxidation gave N-tosyl alpha-amino acids without epimerization.

• 出版日期2010