科研之友
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摘要
A direct intermolecular cross-benzoin-type condensation catalyzed by an N-heterocyclic carbene has been developed. The cross-coupling of commercially available aromatic aldehydes and trifluoromethyl ketones results in alpha-hydroxy-alpha-trifluoromethyl ketones bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields.
- 出版日期2009-8
