Decreased Glucose Transporter 1 in Brains With Ischemic Cerebrovascular Diseases

作者：Liu Ying; Jiang Hong^*; Bai Jing; Gong Cheng-Xin

来源：Progress in Biochemistry and Biophysics, 2010, 37(4): 397-401.

DOI：10.3724/SP.J.1206.2009.00658

• ischemic cerebrovascular diseases (ICVD)
• glucose transporter 1 (GLUT1)
• hypoxia-inducible factor-1 alpha (HIF-1 alpha)
• protein O-GlcNAcylation

The entry of glucose from blood into the brain through the blood-brain barrier relies on glucose transporters (GLUT). GLUT1 is the major GLUT in the blood-brain barrier and one of the molecular markers of the endothelial cells of brain capillaries. It has been demonstrated that GLUT1 expression is increased after acute cerebral ischemia in animal models. GLUT1 level in brain tissue from 7 cases of chronic ischemic: cerebrovascular diseases (ICVD) were determined and compared with that from 1 I cases of the age- and postmortem interval-matched controls. It was found that GLUT I level was decreased markedly in ICVD, and this decrease appeared to result from a down-regulation of hypoxia-inducible factor-1 alpha.(HIF-1 alpha). It was also found that the level of protein O-GlcNAcylation was not altered in the ICVD brain. These results shed new light into the molecular mechanism of ICVD.

• 出版日期2010-4
• 单位武汉大学