A prospective study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in malignant lymphoma patients following highly emetogenic chemotherapy

作者：Takahashi Tsutomu; Okada Takahiro; Ikejiri Fumiyoshi; Ito Shunsuke; Okada Yusuke; Takahashi Fumimasa; Kumanomido Satoshi; Jo Yumi; Adachi Koji; Onishi Chie; Kawakami Koshi; Miyake Takaaki; Inoue Masaya; Suzuki Ritsuro; Suzumiya Junji

来源：International Journal of Clinical Oncology, 2018, 23(1): 189-194.

DOI：10.1007/s10147-017-1173-3

• Chemotherapy
• Nausea
• Vomiting
• Lymphoma
• Palonosetron

Chemotherapy-induced nausea and vomiting (CINV) is a troublesome issue in chemotherapy for cancer patients. A second-generation 5HT(3) receptor antagonist (5HT(3)RA), palonosetron, is effective and safe for the prevention of CINV in breast cancer patients treated with cyclophosphamide and anthracycline, but there is little data for malignant lymphoma. We conducted a prospective phase 2 study at a single institution to clarify the efficacy and safety of palonosetron in lymphoma patients.
Chemotherapy-na < ve lymphoma patients who were treated with highly emetogenic chemotherapy (HEC) received a single intravenous bolus of palonosetron, 0.75 mg/body, before chemotherapy on day 1 during the first course of chemotherapy. The occurrence of CINV was assessed using the Multinational Association for Supportive Care in Cancer (MASCC) antiemesis tool, which was recorded by patients during the first course of chemotherapy.
A total of 59 patients were enrolled, and 49 patients were eligible and evaluated. The complete response (CR) rate was 93.9% (95% confidence interval 83.1-98.7%) at 0-120 h post-chemotherapy. The proportion of patients who developed nausea of any grade and vomiting at 0-120 h post-chemotherapy was 34.7 and 6.1%, respectively. Although treatment-related adverse events were observed in 36 (73.5%) patients, these were mild and they recovered by the next cycle of chemotherapy.
The present study demonstrated that a single dose of palonosetron was highly effective and safe for the prevention of CINV in lymphoma patients.

• 出版日期2018-2