Distinctions Between Clinicopathological Factors and Prognosis of Alpha-fetoprotein Negative and Positive Hepatocelluar Carcinoma Patients

作者：Xu Jia; Liu Chang^*; Zhou Lei; Tian Feng; Tai Ming Hui; Wei Ji Chao; Qu Kai; Meng Fan Di; Zhang Ling Qiang; Wang Zhi Xin; Zhang Jing Yao; Chang Hu Lin; Liu Si Nan; Xu Xin Shen; Song Yan Zhou; Liu Jun; Zhang Peng

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(2): 559-562.

DOI：10.7314/APJCP.2012.13.1.559

• Clinicopathological factors
• prognosis
• alpha-fetoprotein status
• hepatocellular carcinoma

Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP <= 20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.

• 出版日期2012
• 单位西安交通大学