科研之友
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摘要
Angiotensin II type 1 receptor antibodies (AT(1)RAb) have emerged as non-HLA Ab present in patients with acute AMR and risk of graft loss. Furthermore, AT(1)RAb have been shown to increase angiotensin II sensitivity which may play a role in the development of CVD and hypertension. Data on AT(1)RAb in stable transplant recipients are lacking. The aim of this study was to analyze the levels of AT(1)RAb in a cohort of stable patients after kidney transplantation (tx) in childhood. A cross-sectional study of 30 children (median age 14, range 3-19 yr, median time since tx five yr) and 28 adults who were transplanted in childhood (median age 26, range 20-40 yr, median time since tx 18 yr) transplanted between 1993-2006 and 1983-2002, respectively, was performed. Healthy controls were 51 healthy children (5-8 yr) and 199 healthy donors (median age 56.5 yr, range 42-83 yr). Plasma AT(1)RAb were analyzed by immunoassay. Median total AT(1)RAb IgG concentration was significantly higher in the pediatric-tx group as compared to the adult-tx group (40.0 and 10.95 U/mL, p < 0.0001). For both groups, the tx group showed higher levels: the pediatric-tx group vs. control group (40.0 vs. 13.3 U/mL, p = 0.0006) and the adult-tx group vs. adult control group (10.95 vs. 6.5 U/mL, p < 0.0001). Age was the strongest indicator of high levels of AT(1)RAb IgG (p = 0.0003). AT(1)RAb total IgG levels are significantly higher in a stable pediatric-tx cohort as compared to adult-tx patients and healthy controls of comparable age groups. The relevance of our findings in relation to age, time since tx, previous or future rejection, and CVD risk merits future studies.
- 出版日期2016-8
