Adrenocortical carcinoma: The management of metastatic disease

作者:Fay Andre P; Elfiky Aymen; Telo Gabriela H; Mckay Rana R; Kaymakcalan Marina; Nguyen Paul L; Vaidya Anand; Ruan Daniel T; Bellmunt Joaquim; Choueiri Toni K*
来源:Critical Reviews in Oncology/Hematology, 2014, 92(2): 123-132.
DOI:10.1016/j.critrevonc.2014.05.009

摘要

Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing understanding of the molecular pathogenesis of this malignancy as well as multidisciplinary and multi-institutional collaborative efforts will result in better defined targets and subsequently, effective novel therapies.

  • 出版日期2014-11