Association of Anti-Ro/Sjogren's syndrome type A Antibodies and Complete Atrioventricular Block in an Adult With Sjogren's Syndrome

作者：Tam Weng Kin^*; Hsu Hui Ching; Hsieh Ming Hsiung; Yeh Jong Shiuan; Tam Weng Chio^*

来源：Archives of Rheumatology, 2018, 33(2): 225-229.

DOI：10.5606/ArchRheumatol.2018.6492

• Anti-Ro/Sjogren's syndrome type A antibodies
• complete atrioventricular block
• Sjogren's syndrome

A 57-year-old female patient with underlying hypertension, dyslipidemia, membranous glomerulonephritis, and Sjogren's syndrome (SS) presented to our clinic with near-syncope and dizziness symptoms. We detected non-conducted sinus beat in 12-lead electrocardiography. An echocardiography showed that the left ventricular systolic function was preserved without a regional wall abnormality. The patient did not have symptoms of congestive heart failure or recent myocardial infarction. We observed complete atrioventricular block (CAVB) with longest pause of 6.2 seconds in a 24-hour Holter electrocardiography, and subsequently implanted a permanent pacemaker. Anti-Ro/SS type A antibodies are commonly seen in SS and associated with a neonatal complete heart block. The pathogenesis of anti-Ro/SS type A antibodies in the conduction system of an adult heart is still uncertain. In this article, we report SS in an adult patient with CAVB and membranous glomerulonephritis, which may be associated with a positive titer of anti-Ro/SS type A antibodies.

• 出版日期2018-6