Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

作者：Abdelkader Mohamed S A; Philippon Thomas; Asenjo Juan A; Bull Alan T; Goodfellow Michael; Ebel Rainer; Jaspars Marcel; Rateb Mostafa E^*

来源：Journal of Antibiotics, 2018, 71(4): 425-431.

DOI：10.1038/s41429-017-0012-0

Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive beta-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-beta-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

• 出版日期2018-3