LOVASTATIN IMPROVES FLUORIDE-INDUCED HYPERCHOLESTEROLEMIA IN ALBINO RATS

作者：Karn Sanjay S; Pandavadara Sanjay B; Vasant Rupal A; Narasimhacharya Avrl^*

来源：Fluoride, 2014, 47(1): 69-77.

• Antioxidant status
• Hypercholesterolemia
• Lovastatin
• Oxidative stress
• Statins

Fluoride (F) is an environmental contaminant in many countries and, the chronic intake of F alters the body physiology, especially for lipid and antioxidant metabolism. Since F is reported to cause hypercholesterolemia leading progressively to hyperlipidemic conditions and people residing in endemic F areas are likely candidates for hypercholesterolemia and cardiovascular diseases, the present work was designed to investigate the efficacy of a standard drug lovastatin in F-induced hypercholesterolemia. A comparison was made, in rats, between F-exposed, high cholesterol diet, and F-exposed + high cholesterol diet animals with special reference to the utility of lovastatin in normalizing the plasma and tissue lipids and the antioxidant profiles. The results indicated that both F-exposed and F-exposed + high cholesterol diet animals registered higher lipid profiles with a reduction in antioxidant status. However, the F-exposed + high cholesterol diet fed animals were more affected than the F-exposed animals. Lovastatin administration caused a significant decline in lipid profiles and improved the antioxidant status of the F-exposed and F-exposed + high cholesterol diet animals significantly besides being effective in the high cholesterol diet rats. Thus the results indicated that lovastatin might be considered for treating hypercholesterolemia in F endemic areas. However, it was noted that statins may have limited or no efficacy in reducing overall mortality and carry significant adverse effect risks including for muscle pain, memory impairment, reduced energy, and exertional fatigue.

• 出版日期2014-3