Dual-sugar imaging using isonitrile and azido-based click chemistries

作者:Wainman Yelena A; Neves Andre A; Stairs Shaun; Stoeckmann Henning; Ireland Zecchini Heather; Brindle Kevin M; Leeper Finian J*
来源:Organic and Biomolecular Chemistry, 2013, 11(42): 7297-7300.
DOI:10.1039/c3ob41805g

摘要

We report the first account of metabolically labelling N-acetylglucosamine, in conjunction with either N-acetylgalactosamine or N-acetylmannosamine using a combination of isonitrile- and azide-based chemistries. With the appropriately labelled fluorescent probe molecules, that react with either the azido or isonitrile groups, the method enabled co-visualisation of cancer cell glycoproteins.

  • 出版日期2013-11-14