Feasibility of Image-Guided Radiotherapy and Concurrent Chemotherapy for Locally Advanced Nonsmall Cell Lung Cancer

作者：Nguyen Nam P^*; Kratz Sarah; Chi Alexander; Vock Jacqueline; Vos Paul; Shen Wei; Vincent Vinh Hung; Ewell Lars; Jang Siyoung; Altdorfer Gabor; Karlsson Ulf; Godinez Juan; Woods William; Dutta Suresh; Ampil Fred

来源：Cancer Investigation, 2015, 33(3): 53-60.

DOI：10.3109/07357907.2014.1001896

• NSCLC
• Locally advanced
• Chemoradiation
• IGRT

A retrospective review of 32 patients with stage III nonsmall cell lung cancer who underwent chemoradiation with image-guided radiotherapy (IGRT) was recorded. Acute grade 3-4 hematologic and esophageal toxicities developed in 6 and 13 patients respectively. At a median follow-up of 14.5 months, only one patient developed grade 3 pneumonitis. The median survival was estimated to be 17 months. Five patients (15%) developed loco-regional recurrences, and 17 patients (53%) distant metastases. Grade 3-4 toxicities remained significant during chemoradiation with IGRT. However, the reduced rate of severe pneumonitis despite a high tumor dose is encouraging and needs to be investigated in future prospective studies.

• 出版日期2015-3