MicroRNA-137 inhibits growth of glioblastoma through EGFR suppression

作者：Zhang, Zhenxing; Song, Xiaofeng^*; Tian, He; Miao, Ye; Feng, Xu; Li, Yang; Wang, Honglei

来源：American Journal of Translational Research, 2017, 9(3): 1492-1499.

• Glioblastoma multiforme (GBM)
• miR-137
• epidermal growth factor receptor (EGFR)

Aberrant expression of certain microRNAs (miRNAs) has been shown to contribute to the development of Glioblastoma multiforme (GBM). However, the involvement of miR-137 in the carcinogenesis of GBM has not been reported. Here, we showed that miR-137 levels in GBM tissues were significantly lower than the paired normal brain tissue in patients' specimens. Moreover, low miR-137 levels in GBM tissue were associated with poor prognosis. In vitro, overexpression of miR-137 decreased GBM cell growth and increased cell apoptosis, while depletion of miR-137 enhanced cell growth and decreased cell apoptosis. Combined bioinformatics analysis and dual luciferase reporter assay showed that miR-137 may target the 3'-UTR of the epidermal growth factor receptor (EGFR) to reduce its protein translation, resulting in suppression of EGFR signaling in GBM cells. Together, our data suggest that reduction in miR-137 levels in GBM tissues may increase cell growth and decrease cell apoptosis, possibly through suppression of EGFR.

• 出版日期2017
• 单位锦州医科大学