科研之友
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摘要
Whereas vascular aging has been identified as an emerging cardiovascular risk factor, definitions of %26apos;normal%26apos; and %26apos;early%26apos; vascular aging (EVA) and their precise relationship with cardiovascular risk are currently equivocal. The present review discusses the concept of vascular aging; that structural and functional changes occur in the large arteries with aging; and EVA; that such age-associated changes are accelerated in individuals at increased cardiovascular risk; and their metrics; indeed, in order to provide a definition of when EVA occurs in clinical practice, reference values of normal and accelerated vascular aging are needed. Due to the complex nature of age-associated changes in the large arteries described above, there are different parameters relating to vascular aging which can be measured. These broadly include aortic and carotid stiffening; aortic and carotid lumen dilation; endothelial dysusually measured via brachial flow-mediated dilatation); and carotid intima-media thickness.
- 出版日期2012-6
