A Convenient Synthesis and Biological Activity of Novel Thieno[2,3-c]Pyrazole Compounds as Antimicrobial and Anti-Inflammatory Agents

作者：El Dean Adel M Kamal; Zaki Remon M^*; Abdulrazzaq Abdullah Y

来源：Russian Journal of Bioorganic Chemistry, 2015, 41(1): 97-104.

DOI：10.1134/S1068162015010057

• synthesis
• reactions
• thienopyrazole
• thienopyrazolopyrimidine
• thienopyrazoloimidazolopyrimidine

A new method for synthesizing 4-amino-3-methyl-1-phenyl-1H-5-substituted thieno [2,3-cipyrazole was reported. The substituted groups at position 5 include carbonitrile, carboxamide, N-phenyl carboxamide, and benzoyl groups. The newly synthesized compounds and their derivatives were characterized by elemental analysis and spectroscopy (IR, H-1 NMR, and mass spectra). Furthermore, some of these synthesized compounds were screened against various pathogenic bacterial and fungal strains. The results demonstrate that most of the synthesized compounds possess a significant antibacterial activity against gram-positive and gram-negative bacteria. In addition, most of these compounds showed a remarkable anti-fungal activity. On the other hand, some of the synthesized compounds possess high anti-inflammatory activity, which was demonstrated using the carrageenan-induced rat paw edema assay.

• 出版日期2015-1