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摘要
CO32- doping is an effective method to increase the biological activity of nano-hydroxyapatite (n-HA). In the present study, calcium nitrate and trisodium phosphate were chosen as raw materials, with a certain amount of Na2CO3 as a source of CO32- ions, to synthesize nano-carbonate hydroxyapatite (n-CHA) slurry by solution precipitation method. The structure and micro-morphology of n-CHA were characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR) and Raman spectroscopy (RS). The results revealed that the synthetic n-HA crystals are. acicular in nanometer scale and have a crystal size of 20 similar to 30 nm in diameter and 60 similar to 80 nm in length, which are similar to natural bone apatite. And the crystallinity of n-CHA crystals decreases to the increment of CO32-. Samples with more CO32 have composition and structure more similar to the bone apatite. The value of lattice parameters a decreases, value of c increases, and c/a value increases with the increase in the amount of CO32-, in accordance with crystal cell parameters change rule of type B replacement. In the AB mixed type (substitution OH- and PO43-) CHA, IR characteristic peak of CO32- out-of-plane bending vibration appears at 872 cm(-1), meanwhile, the asymmetry flexible vibration band is split into band at 1 454 cm(-1) and band at 1 420 cm(-1), while weak CO32--peak appears at 1 540 cm(-1). CO32- Raman peak of symmetric stretching vibration appears at 1 122 cm(-1). CO32- B-type (substitution PO43-) peak appeared at 1 071 cm(-1). Through the calculation of integral area ratio of PO43-/CO32-, OH-/CO32-, and PO43-/OH-, low quantity CO32- is B-type and high quantity CO32- is A-type (substitution OH-). The results show that the synthesized apatite crystals are AB hybrid substitued nano-carbonate hydroxyapatite, however B-type replacement is the main substitute mode. Due to similarity in the shape, size, crystal structure and growth mode, the synthesized apatite crystals can be called a kind of bone-like apatite.
- 出版日期2014-11
- 单位河南理工大学
