Action of a serotonergic anorectic in meal-fed mice working for food

作者：Rowland Neil E^*; Robertson Kimberly L; Cadiz Emilia M; Kenney Jessica; Kwiatkowski Veronica

来源：Behavioural Pharmacology, 2012, 23(5-6): 560-566.

DOI：10.1097/FBP.0b013e3283566a79

• anorectic drug mouse
• closed economy
• food demand
• norfenfluramine
• satiety
• unit price

The aim of this study was to examine the effects of a serotonergic anorectic agent, dexnorfenfluramine (DNOR), on food intake in mice whose meals were constrained to specified periods each day and by effort. Mice were forced to adopt a human-like pattern of regular meals by making food available for four periods of 40 min/24-h period, mostly at night. They lived in behavior test chambers with a closed economy for food and were required to emit a fixed unit price (FUP) of either 2 or 25 nose pokes (FUP2, FUP25) to receive a 20 mg pellet of food. Once responding and intake were stable, mice were injected with a vehicle or DNOR (3 or 6 mg/kg) 1 h before a specified feeding opportunity. Food intake was dose-dependently suppressed at the next meal and to a greater extent when the cost of food was high (FUP25). Within a meal, the effect of the drug was the greatest in the first half of the available time. Therefore, the anorectic effect of DNOR was modified by the concurrent cost of food.

• 出版日期2012-9