A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

作者：Boyd Scott^*; Davies Christopher D

来源：Tetrahedron Letters, 2014, 55(30): 4117-4119.

DOI：10.1016/j.tetlet.2014.06.024

• Oxetane
• Malonate
• Cyclisation
• Drug discovery
• Medicinal chemistry

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

• 出版日期2014-7-23