Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus

作者：Garcia Carrasco M; Mendoza Pinto C; Munguia Realpozo P; Rodriguez Gallegos A; Vallejo Ruiz V; Munoz Guarneros M; Mendez Martinez S; Soto Santillan P; Pezzat Said E; Reyes Leyva J; Lopez Colombo A; Ruiz Argueelles A; Cervera R^*

来源：Lupus, 2015, 24(6): 606-612.

DOI：10.1177/0961203314559628

• Cervical human papillomavirus infection
• systemic lupus erythematosus
• vitamin D

Our objective was to evaluate whether vitamin D deficiency is associated with cervical human papilloma virus (HPV) infection in women with SLE. This is a cross-sectional study of 67 women with SLE. A structured questionnaire was administered to ascertain the possible risk factors associated with cervical HPV infection. A gynaecological evaluation and cervical cytology screening were made. HPV detection and genotyping was made by PCR and linear array assay. Serum 25 hydroxyvitamin D levels were quantified by chemiluminescence immunoassay. Mean age and disease duration were 44.8 +/- 10.6 and 42.5 +/- 11.8 years, respectively. Demographic characteristics were similar in patients with and without deficiency (<20ng/ml and 20ng/ml). There were 28.4% of women with cervical HPV infection and 68.4% had high-risk HPV infections. Patients with 25 hydroxyvitamin D levels <20ng/ml had a higher prevalence of cervical HPV infection than those with levels 20ng/ml (30.7% vs. 25.8%; p=0.72). We found no significant difference when high-risk HPV infection was evaluated (36.8% vs. 31.5%; p=0.73). In conclusion, women with SLE have a high prevalence of vitamin D deficiency and cervical HPV infection. However, we found no association between vitamin D deficiency and cervical HPV.

• 出版日期2015-5