A Molecular Magnet Confined in the Nanocage of a Globular Protein

作者：Mitra Rajib K; Verma Pramod K; Wulferding Dirk; Menzel Dirk; Mitra Tamoghna; Todea Ana M; Lemmens Peter^*; Mueller Achim; Pal Samir K

来源：ChemPhysChem, 2010, 11(2): 389-393.

DOI：10.1002/cphc.200900708

• energy transfer
• molecular dynamics
• magnetic properties
• protein structures
• vanadates

The effect of confinement and energy transfer on the dynamics of a molecular magnet, known as a model system to study quantum coherence, is investigated. For this purpose the well-known polyoxovanadate [V15As6O42(H2O)](6-) (V-15) is incorporated into a protein (human serum albumin, HSA) cavity. Due to a huge overlap of the optical absorption spectrum of V, with the emission spectrum of a fluorescence center of HSA (containing a single tryptophan residue), energy transfer is induced and probed by steady-state and time-resolved fluorescence. The geometrical coordination and the distance of the confined V-15 to the tryptophan moiety of HSA are investigated at various temperatures. This effect is used as a local probe for the thermal denaturation of the protein at elevated temperatures.

• 出版日期2010-2-1