Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers

作者：Martini Elisabetta; Salvicchi Alberto; Ghelardini Carla; Manetti Dina; Dei Silvia; Guandalini Luca; Martelli Cecilia; Melchiorre Michele; Cellai Cristina; Scapecchi Serena; Teodori Elisabetta; Romanelli Maria Novella^*

来源：Bioorganic & Medicinal Chemistry, 2009, 17(21): 7606-7614.

DOI：10.1016/j.bmc.2009.08.055

• Sunifiram
• Sapunifiram
• Cognition-enhancers
• Mouse passive-avoidance test

A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds.

• 出版日期2009-11-1