Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naive ultra-high-risk subjects and first-episode schizophrenia

作者：Nenadic Igor^*; Maitra Raka; Basu Soumyajit; Dietzek Maren; Schoenfeld Nils; Lorenz Carsten; Gussew Alexander; Amminger G Paul; McGorry Patrick; Reichenbach Juergen R; Sauer Heinrich; Gaser Christian; Smesny Stefan

来源：European Neuropsychopharmacology, 2015, 25(10): 1661-1668.

DOI：10.1016/j.euroneuro.2015.05.005

• Magnetic resonance spectroscopy (MRS)
• Prefrontal cortex (PFC)
• Psychosis
• Schizophrenia
• Voxel-based morphometry (VBM)

Hippocampal pathology has been shown to be central to the pathophysiology of schizophrenia and a putative risk marker for developing psychosis. We applied both H-1 MRS (proton magnetic resonance spectroscopy) at 3 Testa and voxel-based morphometry (VBM) of high-resolution brain structural images in order to study the association of the metabolites glutamate (Glu) and N-acetyl-aspartate (NAA) in the hippocampus with whole-brain morphometry in 31 persons at ultra-high-risk for psychosis (UHR), 18 first-episode schizophrenia patients (Sz), and 42 healthy controls (all subjects being neuroleptic-naive). Significantly diverging associations emerged for UHR subjects hippocampal glutamate showed positive correlation with the left superior frontal cortex, not seen in Sz or controls, while in first-episode schizophrenia patients a negative correlation was significant between glutamate and a left prefrontal area. For NAA, we observed different associations for left prefrontal and caudate clusters bilaterally for both high-risk and first-episode schizophrenia subjects, diverging from the pattern seen in healthy subjects. Our results suggest that associations of hippocampal metabolites in key areas of schizophrenia might vary due to liability to or onset of the disorder.

• 出版日期2015-10