A tandem and fully enzymatic procedure for the green resolution of chiral alcohols: acylation and deacylation in non-aqueous media

作者：Wang, Bo; Jiang, Ling; Wang, Jue; Ma, Jingbo; Liu, Min; Yu, Hongwei^*

来源：Tetrahedron: Asymmetry , 2011, 22(9): 980-985.

DOI：10.1016/j.tetasy.2011.05.022

• ASYMMETRIC-SYNTHESIS
• ESCHERICHIA-COLI
• DEACETYLATION
• CHEMISTRY
• ESTERASE
• LIPASES
• BIOH

A green and fully enzymatic procedure for the resolution of chiral alcohols through lipase/esterase-catalyzed acylation and subsequent lipase-catalyzed aminolysis using anhydrous ammonia was demonstrated. Both enantiomers can be obtained in high ee values (up to >99%) under ambient reaction conditions. The solvent and acyl donors can be recycled, and the enzyme can be reused for up to five times.

• 出版日期2011-5-15
• 单位浙江大学