Uses of 1-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)-3-dodecanoylthioure a as a Building Block in the Synthesis of Fused Pyrimidine and Thiazine Systems

作者：Hemdan Magdy Mohamed^*; Abd El Mawgoude Heba Kamal

来源：Chemical & Pharmaceutical Bulletin, 2015, 63(6): 450-456.

DOI：10.1248/cpb.c15-00047

• lauroyl isothiocyanate
• pyrimidine derivative
• fused system
• 2-amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carbonitrile

The reaction of lauroyl isothiocyanate and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was used to synthesize the title compound 2. Compound 2 could serve as the main building block in the synthesis of many target heterocyclic systems. Various fused pyrimidines were synthesized in the reactions of compound 2 with sodium ethoxide, hydrazine hydrate, phenyl hydrazine, ethyl carbazate, thiourea, and/or 2-aminothiophenol. The structures of the synthesized compounds were confirmed by microanalytical and spectral data.

• 出版日期2015-6