Update on the treatment of tuberculosis in children

作者：Brinkmann F^*; Thee S

来源：Monatsschrift Kinderheilkunde, 2014, 162(2): 122-129.

DOI：10.1007/s00112-013-2964-x

• Tuberculosis
• Antitubercular agents
• Dosage
• Pharmacokinetics
• Drug resistance

Background. Prevention, diagnosis and therapy of tuberculosis in children remain a challenge. %26lt;br%26gt;Prevention and therapy. Due to increased risk of disease progression after infection, prophylactic treatment with isoniazid (INH) for 3 months in children %26lt;5 years is indicated after contact with infectious patients. Preventive therapy with INH for 9 months or INH and RMP for 3 months is indicated in asymptomatic tuberculosis infection in all children and adolescents. Uncomplicated primary tuberculosis in children can sufficiently be treated with an initial combination of three drugs. %26lt;br%26gt;Conclusion. Especially in small children, rapid diagnosis and treatment is crucial because of an increased risk of disseminated tuberculosis. Drug-resistant tuberculosis is challenging and requires specialist expertise.

• 出版日期2014-2