A practical and efficient synthesis of bis(indolyl)methanes in water, and synthesis of di-, tri-, and tetra(bis-indolyl)methanes under thermal conditions catalyzed by oxalic acid dihydrate

作者：Ghorbani Vaghei Ramin^*; Veisi Hojat; Keypour Hassan; Dehghani Firouzabadi Ahmad Ali

来源：Molecular Diversity, 2010, 14(1): 87-96.

DOI：10.1007/s11030-009-9150-z

• Di-, tri-, and tetra(bis-indolyl)methanes
• Oxalic acid dihydrate
• CTAB
• Water

A simple, clean, and highly efficient green protocol has been developed for synthesis of bis(indolyl), di(bis-indolyl), and tris-indolyl methanes by the reaction of indole with aldehydes and ketones irn the presence of oxalic acid dihydrate [(CO(2)H)(2)center dot 2H(2)O] and N-cetyl-N, N, N-trimethylammonium bromide (CTAB) in water. Also, tri(bis-indolyl) and tetra(bis-indolyl)methanes as new bis(indolyl)methanes were prepared under thermal conditions.

• 出版日期2010-2