A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis

作者：Ligocki A J; Lovato L; Xiang D; Guidry P; Scheuermann R H; Willis S N; Almendinger S; Racke M K; Frohman E M; Hafler D A; O'Connor K C; Monson N L^*

来源：Journal of Neuroimmunology, 2010, 226(1-2): 192-193.

DOI：10.1016/j.jneuroim.2010.06.016

• Multiple sclerosis
• B lymphocytes
• Antibody gene rearrangement
• Somatic hypermutation
• CNS tissue

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.

• 出版日期2010-9-14