A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp

作者：Senadeera Sarath P D; Wiyakrutta Suthep; Mahidol Chulabhorn; Ruchirawat Somsak; Kittakoop Prasat^*

来源：ORGANIC %26 BIOMOLECULAR CHEMISTRY, 2012, 10(35): 7220-7226.

DOI：10.1039/c2ob25959a

Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher%26apos;s method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated.

• 出版日期2012