Association of Areca Nut Chewing With Risk of Erectile Dysfunction

作者：Huang Yung Jui; Jiann Bang Ping^*

来源：Sexual Medicine, 2017, 5(3): E163-E168.

DOI：10.1016/j.esxm.2017.05.002

• Areca Nut
• Betel Inflorescence
• Erectile Dysfunction
• Psychoactive Substance

Introduction: Areca nut chewing has been shown to increase the risk of cardiovascular disease, but its association with erectile dys ED) has not been investigated.
Aim: To investigate the association between areca nut chewing and risk of ED.
Methods: Consecutive men at public health centers for oral malignancy screening or health checkup were invited to complete a questionnaire.
Main Outcome Measure: The Sexual Health Inventory for Men (SHIM).
Results: Of the 2,652 respondents, 1,038 (mean age = 43.8 +/- 11.1 years) were eligible for the areca nut chewing group and 1,090 non-areca nut chewers were selected as the age-matched control group. In the areca nut group, the mean duration of chewing was 13.2 +/- 9.6 years, 61.7% consumed more than 10 portions per day, and 76.2% used it with betel leaf, 16.7% used it with betel inflorescence, and 7.1% used it with betel leaf and inflorescence. Smoking, alcohol drinking, obesity, hypertension, and diabetes were more predominant in areca nut chewers compared with controls. ED defined by self-report and by SHIM score was more prevalent in areca nut chewers than in controls (13.7% vs 9.8% and 48.7% vs 43.3%, respectively; P < .05 for the two comparisons). Areca nut use with betel inflorescence was associated with a higher risk of ED (odds ratio = 2.25, 95% confidence interval = 1.55-3.28) with a dose-dependent effect, whereas using it with betel leaf was not (odds ratio = 1.00, 95% confidence interval = 0.79-1.26) after adjustment of possible confounders.
Conclusion: Areca nut chewing with betel inflorescence was associated with an increased risk of ED. These findings warrant further studies.

• 出版日期2017