A transcriptomic approach to predict the impact of beta-(1,3)-polyglucuronic acid sodium salt and derivatives in the main biological processes

作者：Delattre C^*; Michaud P; Chaisemartin L; Berthon J Y; Rios L

来源：Carbohydrate Polymers, 2012, 87(2): 1828-1836.

DOI：10.1016/j.carbpol.2011.10.010

• beta-(1,3)-Polyglucuronic acid sodium salt
• Biological processes
• Curdlan
• DNA-array
• Regioselective oxidation
• Transcriptomic analysis

beta-(1,3)-Polyglucuronic acid sodium salt was produced by the regioselective oxidation of curdlan using 2,2,6,6,-tetramethylpiperidine-1-oxyl radical (TEMPO)/NaBr/NaClO systems. This beta-(1,3)-polyuronic acid sodium salt was depolymerized, O-sulphated and O-acetylated. All these molecules have been biologically screened for transcriptomic analysis using DNA array. The transcriptomical responses were studied after statistical gene ontology in order to evaluate biological responses disturbed by the individual treatments of human fibroblast by all these beta-(1,3)-polyglucuronic acid sodium salt derivatives.

• 出版日期2012-1-15