Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

作者：De Bastiani Rudi; Gabrielli Maurizio^*; Lora Liliana; Napoli Luigi; Tosetti Cesare; Pirrotta Enzo; Ubaldi Enzo; Bertolusso Luciano; Zamparella Maria; De Polo Manuela; Nebiacolombo Cristina; Bortot Mario; Mancuso Maurizio; Bacchin Paolo; Marsala Valerio; Pinna Roberto; Tursi Antonio; Benedetto Edoardo; Cuffari Alfredo; Pati Antonino; Di Caro Simona; Perenzin Gastone; Sala Raffaella; Pinton Giacomo Calzavara; Ga**arrini Antonio

来源：Dermatology, 2015, 230(2): 156-160.

DOI：10.1159/000369615

• Psoriasis
• Immune-mediated diseases
• Coeliac disease
• Primary care

Background: Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results. Objective: To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD. Methods: We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically. Results: Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis. Conclusion: Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.

• 出版日期2015