Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-B-Snail signaling in glioma

作者：Zhang Baogang^*; Shi Lihong; Lu Shijun; Sun Xiuning; Liu Yuqing; Li Hongli; Wang Xuejian; Zhao Chunzhen; Zhang Heng; Wang Ying

来源：Cancer Biology and Therapy, 2015, 16(6): 898-911.

DOI：10.1080/15384047.2015.1028702

• ELMO1
• glioma
• invasion
• IL-8

Glioma is the most common form of primary malignant brain cancers. Tumor cell invasiveness is a critical challenge in the clinical management of glioma patients. The invasive biological feature of glioma cell is stimulated by both autocrine and paracrine factors including chemokine IL-8. In this study, we report that the production of IL-8 is higher in glioma tissues and cells than adjacent nontumor tissues (ANT) and normal glial cells. Autocrine IL-8 can increase the invasive ability of glioma cells by binding to CXCR1. In addition, high expression of IL-8 indicates poor prognosis of glioma patients. Furthermore, IL-8 is capable of modulating cell migration and invasion by regulating the activation of RAC1 which resulted in cytoskeletal reorganisation in an ELMO1 dependent manner. Finally, we found that IL-8 could enhance mesenchymal transition(MT) of glioma cells by activating ELMO1-NF-B-Snail signaling. Our data indicate that IL-8 autocrine is responsible for the invasive phenotype of glioma and IL-8 may be a useful prognostic marker for glioma and novel therapeutic target for glioma invasion intervention.

• 出版日期2015-6
• 单位潍坊医学院