High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma

作者：Linnemann, Carsten; van Buuren, Marit M.; Bies, Laura; Verdegaal, Els M. E.; Schotte, Remko; Calis, Jorg J. A.; Behjati, Sam; Velds, Arno; Hilkmann, Henk; el Atmioui, Dris; Visser, Marten; Stratton, Michael R.; Haanen, John B. A. G.; Spits, Hergen; van der Burg, Sjoerd H.; Schumacher, Ton N. M.^*

来源：Nature Medicine, 2015, 21(1): 81-85.

DOI：10.1038/nm.3773

• CD4+T CELLS
• B-CELLS
• TUMOR
• PATIENT
• IDENTIFICATION
• REACTIVITY
• GENES

Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma.

• 出版日期2015-1