Migration and Homeostasis of Naive T Cells Depends on Coronin 1-Mediated Prosurvival Signals and Not on Coronin 1-Dependent Filamentous Actin Modulation

作者：Mueller Philipp; Liu Xiaolong; Pieters Jean^*

来源：The Journal of Immunology, 2011, 186(7): 4039-4050.

DOI：10.4049/jimmunol.1003352

Coronins are WD repeat-containing proteins highly conserved in the eukaryotic kingdom implicated in the regulation of F-actin. Mammalian coronin 1, one of the most conserved isoforms expressed in leukocytes, regulates survival of T cells, which has been suggested to be due to its role in preventing F-actin-induced apoptosis. In this study, we come to a different conclusion. We show that coronin 1 does not modulate F-actin and that induction of F-actin failed to induce apoptosis. Instead, coronin 1 was required for providing prosurvival signals, in the absence of which T cells rapidly underwent apoptosis. These results argue against a role for coronin 1 in F-actin-mediated T cell apoptosis and establish coronin 1 as an essential regulator of the balance between prosurvival and proapoptotic signals in naive T cells. The Journal of Immunology, 2011, 186: 4039-4050.

• 出版日期2011-4-1