Dutasteride is associated with reduced risk of transrectal prostate biopsy-associated urinary tract infection and related hospitalizations

作者：Moreira Daniel M; Andriole Gerald L; Nickel J Curtis; Roehrborn Claus G; Castro Santamaria Ramiro; Freedland Stephen J

来源：World Journal of Urology, 2017, 35(10): 1525-1530.

DOI：10.1007/s00345-017-2036-2

• 5-Alpha-reductase inhibitors
• Biopsy
• Double-blind method
• Dutasteride
• Humans
• Male
• Middle aged
• Urinary tract infection

Objectives To evaluate whether the use of dutasteride is associated with a lower risk of transrectal prostate biopsyassociated urinary tract infection ( TPBA-UTI) among men in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study.
Methods Retrospective analysis of 6045 men undergoing 2-year repeat prostate biopsy in REDUCE. Participants were randomized to receive dutasteride 0.5 mg or placebo daily. TPBA-UTI was defined as the presence of urinary symptoms and the prescription of antibiotics by the treating physician within 30 days after biopsy. Severe TPBA-UTI was defined as TPBA-UTI requiring hospitalization. Comparison of TPBA-UTI between treatment arms was done using Chi-square test and logistic regression adjusting for participant characteristics.
Results Of the subjects included in the study, 3067 ( 50.7%) were randomized to the placebo arm and 2978 ( 49.3%) tothe dutasteride arm. A total 51 (0.8%) men had TPBA-UTI, including 38 (1.2%) in the placebo arm and 13 (0.4%) in the dutasteride arm (univariable relative risk [RR] = 0.35, P = 0.001; multivariable odds ratio [OR] = 0.34, P = 0.003). The number needed to treat (NNT) to prevent one TPBA-UTI was 125 subjects. Of these, 14 (28%) had severe TPBA-UTI, including 12 (0.4%) in the placebo arm and only 2 (0.07%) in the dutasteride arm (univariable RR = 0.17, P = 0.021; multivariable OR = 0.17, P = 0.031). The NNT to prevent one severe TPBA-UTI was 309 subjects.
Conclusion Among men undergoing a 2-year repeat prostate biopsy, the use of dutasteride for 2 years was associated with a reduced the risk of overall and severe TBPA-UTI.

• 出版日期2017-10