New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development

作者：Kurashima Yosuke; Kiyono Hiroshi^*

来源：Experimental and Molecular Medicine, 2014, 46(3): e83.

DOI：10.1038/emm.2014.7

• food allergy
• intestinal inflammation
• mucosal mast cells

To achieve immune homeostasis in such a harsh environment as the intestinal mucosa, both active and quiescent immunity operate simultaneously. Disruption of gut immune homeostasis leads to the development of intestinal immune diseases such as colitis and food allergies. Among various intestinal innate immune cells, mast cells (MCs) play critical roles in protective immunity against pathogenic microorganisms, especially at mucosal sites. This suggests the potential for a novel MC-targeting type of vaccine adjuvant. Dysregulated activation of MCs also results in inflammatory responses in mucosal compartments. The regulation of this yin and yang function of MCs remains to be elucidated. In this review, we focus on the roles of mucosal MCs in the regulation of intestinal allergic reaction, inflammation and their potential as a new target for the development of mucosal adjuvants.

• 出版日期2014-3
• 单位河北医科大学