Association of plasma vitamin D status with lifestyle patterns and ambulatory blood pressure monitoring parameters in patients with type 2 diabetes and hypertension

作者：Rabello Moreira Juliano Soares; de Paula Tatiana Pedroso; Sperb Luiza Ferreira; Peinado Miller Maria Elisa; Azevedo Mirela Jobim; Viana Luciana Vercoza

来源：Diabetes Research and Clinical Practice, 2018, 139: 139-146.

DOI：10.1016/j.diabres.2018.02.038

• Vitamin D
• Blood pressure
• Type 2 diabetes
• Lifestyle

Aims: To evaluate nutritional and metabolic parameters associated with vitamin D status and blood pressure (BP) in type 2 diabetes and hypertensive patients.
Methods: BP evaluated by office and 24-h ambulatory BP monitoring (ABPM). Physical activity was evaluated by daily step count, body composition by DXA, and diet by a food frequency questionnaire.
Results: 116 patients were evaluated and median 25-hydroxyvitamin D level was 21 (16-27) ng/ml; 43% deficient (<20 ng/ml). Vitamin D deficiency was associated with higher systolic ABPM (136 +/- 10 vs. 130 +/- 13 mmHg; P = 0.01) and daytime ABPM (138 +/- 11 vs. 133 +/- 13 mm Hg; P = 0.02), lower step counts (4400 [2700-6600] vs. 6400 [4700-8100] steps/day), lower urinary calcium (47 [32-141] vs. 89 [68-152] mEq), and higher fat mass (31 +/- 8 vs. 27 +/- 6.5 kg). Milk intake (37 vs. 64%; P = 0.009) and fish (31 vs. 69%; P < 0.001) were lower in deficients. On multivariate analysis, adjusted for fat mass and colder seasons, <5000 steps/day (OR = 3.30; 95%CI 1.34-8.12), no milk/fish intake (OR = 6.56; 95%CI 2.52-17.17), and both (OR = 7.24; 95%CI 2.19-23.90) remained associated with vitamin D deficiency.
Conclusions: Vitamin D deficiency was highly prevalent in patients with hypertension and type 2 diabetes and associated with higher systolic ABPM (daytime and 24-h), less physical activity, and no milk or fish intake.

• 出版日期2018-5