Heritability of central blood pressure and arterial stiffness: a twin study

作者：Tarnoki Adam Domonkos^*; Tarnoki David Laszlo; Stazi Maria Antonietta; Medda Emanuela; Cotichini Rodolfo; Nistico Lorenza; Fagnani Corrado; Lucatelli Pierleone; Boatta Emanuele; Zini Chiara; Fanelli Fabrizio; Baracchini Claudio; Meneghetti Giorgio; Osztovits Janos; Jermendy Gyorgy; Preda Istvan; Kiss Robert Gabor; Metneki Julia; Horvath Tamas; Karlinger Kinga; Racz Adel; Lannert Agnes; Molnar Andrea Agnes; Littvay Levente; Garami Zsolt; Berczi Viktor; Schillaci Giuseppe

来源：Journal of Hypertension, 2012, 30(8): 1564-1571.

DOI：10.1097/HJH.0b013e32835527ae

• augmentation index
• environmental effects
• genetics
• pulse pressure
• pulse wave velocity
• twin study

Objective: Central blood pressure and aortic stiffness have been consistently reported as strong cardiovascular risk factors. Twin studies by comparing identical with nonidentical twins produce information on the relative contribution of genes and environment. %26lt;br%26gt;Methods: One hundred and fifty-four monozygotic (MZ) and 42 dizygotic (DZ) twin pairs (age 43 +/- 17 years) from Hungary and the United States underwent brachial and central augmentation index (AIx), brachial and central pressure, and aortic pulse wave velocity (PWV) measurements with the invasively validated Arteriograph device. Bivariate Cholesky decomposition models were applied. %26lt;br%26gt;Results: Age-adjusted, sex-adjusted and country-adjusted heritability was 60.0% for central SBP [95% confidence interval (CI), 44.8-69.6%], 50.1% for aortic PWV (95% CI, 26.0-66.8%), 48.7% for aortic AIx (95% CI, 1.7-74.0%), 46.8% for brachial AIx (95% CI, 1.1-73.8%), 46.7% for central pulse pressure (PP) (95% CI, 12.4-61.4%), and 30.0% for brachial PP (95% CI, 0.0-53.4%). Central SBP and PP had strong bivariate correlations with brachial (r = 0.461 and 0.425) and central AIx (r = 0.457 and 0.419), as well as with aortic PWV (r = 0.341 and 0.292, all P %26lt; 0.001). Brachial PP had a weak correlation with brachial AIx (r = -0.118, P %26lt; 0.05), central AIx (r = -0.122, P %26lt; 0.05), and none with aortic PWV (r = 0.08, P = n.s.). Genetic factors explained a moderate phenotypic correlation between central PP, SBP, brachial SBP and aortic PWV. %26lt;br%26gt;Conclusions: Central systolic and PPs, brachial PP, AIx, aortic PWV are moderately heritable. A moderate genetic covariance among aortic PWV and central PP, central SBP and brachial SBP was found.

• 出版日期2012-8