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摘要
This study analyzed levels of parabens in commercial dentifrices and saliva. HPLC was performed using 35% acetonitrile and measuring absorbance at 254nm. Thirteen toothpastes and five mouthwashes were analyzed. Of these, volunteers used three toothpastes and two mouthwashes, and levels of parabens were analyzed in saliva and water used for mouth rinsing. In toothpastes, the highest concentrations of methylparaben (MP), propylparaben (PP) and n-butylparaben (nBP) were 1.86, 1.42 and 1.87mg/g, respectively. In mouthwashes, the highest concentrations of MP and PP were 0.97 and 0.11mg/mL, respectively. After volunteers used 500mg toothpaste T-1, which contained 895 mu g MP, the first and tenth mouth rinse samples contained means of 64.63 and 1.89 mu g MP, respectively. After rinsing the mouth three or five times, 37 mu g or 18 mu g MP was calculated to remain in the oral cavity, respectively. After using 20mL mouthwash S-1, which contained 19mg MP, 1.53mg MP was calculated to remain in the oral cavity. Immediately after using this mouthwash, the mean salivary concentration of MP was 237 mu g/mL. The daily intake of parabens from dentifrices was predicted to be insignificant compared with the intake from food; however, parabens can be ingested from dentifrices.
- 出版日期2014-12
